Stanford University
Postdoctoral Scholars
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Tobi L. Schmidt

Academic Appointments

  • Postdoctoral Research fellow, Neonatal and Developmental Medicine

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 498-7247

Bio

The focus of my academic training has been on immune cell therapies for the treatment of ovarian cancer, meduloblastoma, and neuroblastoma with special attention given to therapies for breast cancer. My experience includes syngeneic and xenograph cancer models, murine models of orthotopic breast cancer including pre-clinical studies for the advancement of small molecule drugs and combined immune cell therapies. I am currently developing a combination therapy for the treatment of metastatic and minimal residual disease in breast cancer. The therapy seeks to combine the approved chemotherapy, bortezomib, with the much-studied immune cell therapy of cytokine-induced killer cells. While unsuccessful in clinical studies for the treatment of breast cancer, bortezomib has been shown to cause cellular stress in cancer cells leading to the upregulation of surface molecules such as MICA/B. The cytokine-induced killer (CIK) cells are an oncolytic population of NKT cells that recognize and mediate cell killing through the NKG2D receptor for which MICA/B is a ligand. In vitro studies of breast cancer cells treated with bortezomib have shown promising results in that NKG2D ligand expression can be modulated and that this modulation improves CIK cell efficacy. By using bortezomib in combination with the CIK cells we believe that the treatment of metastatic breast cancer can be improved.

Boards, Advisory Committees, Professional Organizations

  • Associate Member, AACR (2011 - present)
  • Member, ASM (2014 - present)
  • Member, AAAS (2013 - present)

Professional Education

Bachelor of Science: Notre Dame de Namur University, Biology (1997)
Doctor of Philosophy: Stanford University, MI-PHD (2010)

Stanford Advisors

Christopher Contag: Postdoctoral Faculty Sponsor

Community and International Work

Publications

Publications

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Publication Topics

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